T-bet kontrolliert nicht nur die Produktion von IFN-γ, sondern beeinflusst in einer Art inverser Rückkoppelung auch die Th2 Zellen. Die funktionelle Ausschaltung. Wetten dass dieser Transkriptionsfaktor Ihr. Lymphom- und Brustkrebspanel bereichert? T-bet (Klon MRQ). Der neue monoklonale Kaninchen-Antikörper. Treg cells; Tbet; Th1-like Tregs; inflammatory bowel disease; inflammation; INFLAMMATORY-BOWEL-DISEASE; INTERFERON-GAMMA; COLONIC-MUCOSA;.
Anti-TBX21 (T-Box 21, T-PET, T-bet, TBET, TBLYM)Wetten dass dieser Transkriptionsfaktor Ihr. Lymphom- und Brustkrebspanel bereichert? T-bet (Klon MRQ). Der neue monoklonale Kaninchen-Antikörper. Ticker: TBET. Währung: USD. Typ: Aktie. Ausgabeart: . Handelssegment: . Nächster Börsenfeiertag: Indizes. Der T-Box-Transkriptionsfaktor TBX21, auch T-Bet genannt, ist ein Protein, das beim Menschen vom TBXGen kodiert wird.
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Product Details. Preparation The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. Concentration 0.
Do not freeze. IF Hsieh CY, et al. J Pharmacol Exp. Products Images. It controls the expression of the TH1 cytokine, interferon-gamma.
Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th T-bet is cooperating with Stat4 signal tranducer and activator of transcription 4 in programming chromatin architecture for Th1 gene expression.
Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps. Szabo SJ, et al. Cell Science Finotto S, et al.
Mullen AC, et al. For research use only. Not for diagnostic use. Not for resale. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses.
This data display is provided for general comparisons between formats. Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team. APC anti-T-bet Antibody. Cat Size Price Quantity Avail.
Save Input string was not in a correct format. Check Availability Need larger quantities of this item? His actions were unpopular, and there was much animosity against him for his mistreatment of civilians and disregard for local culture.
After the Xinhai Revolution —12 toppled the Qing dynasty and the last Qing troops were escorted out of Tibet, the new Republic of China apologized for the actions of the Qing and offered to restore the Dalai Lama's title.
During this time, Tibet fought Chinese warlords for control of the ethnically Tibetan areas in Xikang and Qinghai parts of Kham and Amdo along the upper reaches of the Yangtze River.
The Chinese government denounced the agreement as illegal. When in the s and s the regents displayed negligence in affairs, the Kuomintang Government of the Republic of China took advantage of this to expand its reach into the territory.
Emerging with control over most of mainland China after the Chinese Civil War , the People's Republic of China incorporated Tibet in and negotiated the Seventeen Point Agreement with the newly enthroned 14th Dalai Lama 's government, affirming the People's Republic of China's sovereignty but granting the area autonomy.
Subsequently, on his journey into exile, the 14th Dalai Lama completely repudiated the agreement, which he has repeated on many occasions.
The Dalai Lama had a strong following as many people from Tibet looked at him not just as their political leader, but as their spiritual leader.
Afterwards, the Central People's Government in Beijing renounced the agreement and began implementation of the halted social and political reforms.
In , General Secretary and reformist Hu Yaobang visited Tibet and ushered in a period of social, political, and economic liberalization.
The government halted reforms and started an anti- separatist campaign. All of modern China, including Tibet, is considered a part of East Asia.
Tibet has some of the world's tallest mountains, with several of them making the top ten list. Several major rivers have their source in the Tibetan Plateau mostly in present-day Qinghai Province.
Tibet has been called the "Water Tower" of Asia, and China is investing heavily in water projects in Tibet. The mountain is a holy pilgrimage site for both Hindus and Tibetans.
The Hindus consider the mountain to be the abode of Lord Shiva. The Tibetan name for Mt. Kailash is Khang Rinpoche. Tibet has numerous high-altitude lakes referred to in Tibetan as tso or co.
Western passes receive small amounts of fresh snow each year but remain traversible all year round. Low temperatures are prevalent throughout these western regions, where bleak desolation is unrelieved by any vegetation bigger than a low bush, and where wind sweeps unchecked across vast expanses of arid plain.
The Indian monsoon exerts some influence on eastern Tibet. Northern Tibet is subject to high temperatures in the summer and intense cold in the winter.
Cultural Tibet consists of several regions. These include Amdo A mdo in the northeast, which is administratively part of the provinces of Qinghai, Gansu and Sichuan.
Kham Khams in the southeast encompasses parts of western Sichuan, northern Yunnan , southern Qinghai and the eastern part of the Tibet Autonomous Region.
Tibetan cultural influences extend to the neighboring states of Bhutan , Nepal, regions of India such as Sikkim , Ladakh , Lahaul , and Spiti , Northern Pakistan Baltistan or Balti-yul in addition to designated Tibetan autonomous areas in adjacent Chinese provinces.
There are over settlements in Tibet. Lhasa is Tibet's traditional capital and the capital of Tibet Autonomous Region. Lhasa contains a number of significant temples and monasteries, including Jokhang and Ramoche Temple.
Shigatse is the second largest city in the Tibet AR, west of Lhasa. Gyantse and Qamdo are also amongst the largest. It is governed by a People's Government, led by a Chairman.
In practice, however, the Chairman is subordinate to the branch secretary of the Communist Party of China.
As a matter of convention, the Chairman has almost always been an ethnic Tibetan, while the party secretary has always been ethnically non-Tibetan.
The Tibetan economy is dominated by subsistence agriculture. Due to limited arable land, the primary occupation of the Tibetan Plateau is raising livestock, such as sheep , cattle, goats , camels , yaks , dzo , and horses.
The dogs of Tibet are twice the size of those seen in India, with large heads and hairy bodies. They are powerful animals, and are said to be able to kill a tiger.
During the day they are kept chained up, and are let loose at night to guard their masters' house. The main crops grown are barley , wheat, buckwheat , rye , potatoes, and assorted fruits and vegetables.
These include Tibetan hats, jewelry silver and gold , wooden items, clothing, quilts, fabrics, Tibetan rugs and carpets. Forty percent of the rural cash income in the Tibet Autonomous Region is derived from the harvesting of the fungus Ophiocordyceps sinensis formerly Cordyceps sinensis ; contributing at least 1.
The Qingzang railway linking the Tibet Autonomous Region to Qinghai Province was opened in , but it was controversial. In January , the Chinese government issued a report outlining the discovery of a large mineral deposit under the Tibetan Plateau.
The Chinese government sees this as a way to alleviate the nation's dependence on foreign mineral imports for its growing economy.
However, critics worry that mining these vast resources will harm Tibet's fragile ecosystem and undermine Tibetan culture.
On January 15, , China announced the construction of Tibet's first expressway, the Lhasa Airport Expressway , a The project will cost 1. From January 18—20, , a national conference on Tibet and areas inhabited by Tibetans in Sichuan, Yunnan, Gansu and Qinghai was held in China and a substantial plan to improve development of the areas was announced.
The plan calls for improvement of rural Tibetan income to national standards by and free education for all rural Tibetan children.
It is located in the western suburbs of Lhasa, the capital of the Tibet Autonomous Region. The zone has a planned area of 5.
Zone A developed a land area of 2. It is a flat zone, and has the natural conditions for good drainage.
Historically, the population of Tibet consisted of primarily ethnic Tibetans and some other ethnic groups.
According to tradition the original ancestors of the Tibetan people, as represented by the six red bands in the Tibetan flag , are: the Se, Mu, Dong, Tong, Dru and Ra.
The proportion of the non-Tibetan population in Tibet is disputed. On the one hand, the Central Tibetan Administration of the Dalai Lama accuses China of actively swamping Tibet with migrants in order to alter Tibet's demographic makeup.
Religion is extremely important to the Tibetans and has a strong influence over all aspects of their lives.
Bön is the indigenous religion of Tibet, but has been almost eclipsed by Tibetan Buddhism, a distinctive form of Mahayana and Vajrayana , which was introduced into Tibet from the Sanskrit Buddhist tradition of northern India.
Monks returned to monasteries across Tibet and monastic education resumed even though the number of monks imposed is strictly limited.
Tibetan Buddhism has five main traditions the suffix pa is comparable to "er" in English :. The Chinese government continued to pursue a strategy of forced assimilation and suppression of Tibetan Buddhism, as demonstrated by the laws designed to control the next reincarnation of the Dalai Lama and those of other Tibetan eminent lamas.
Monks and nuns who refused to denounce the Dalai Lama have been expelled from their monasteries, imprisoned, and tortured.
The first Christians documented to have reached Tibet were the Nestorians , of whom various remains and inscriptions have been found in Tibet.
Roman Catholic Jesuits and Capuchins arrived from Europe in the 17th and 18th centuries. These included the Jesuit Father Ippolito Desideri , —, who gained a deep knowledge of Tibetan culture, language and Buddhism, and various Capuchins in —, — and —,  Christianity was used by some Tibetan monarchs and their courts and the Karmapa sect lamas to counterbalance the influence of the Gelugpa sect in the 17th century until in when all the missionaries were expelled at the lama's insistence.
Famous earlier missionaries include James O. Proselytising has been illegal in China since But as of [update] , many Christian missionaries were reported to be active in Tibet with the tacit approval of Chinese authorities, who view the missionaries as a counterforce to Tibetan Buddhism or as a boon to the local economy.
Muslims have been living in Tibet since as early as the 8th or 9th century. In Tibetan cities, there are small communities of Muslims , known as Kachee Kache , who trace their origin to immigrants from three main regions: Kashmir Kachee Yul in ancient Tibetan , Ladakh and the Central Asian Turkic countries.
Islamic influence in Tibet also came from Persia. Which became main cause of the cultural separation of the people of Baltistan from the mainstream Tibet.
After a group of Tibetan Muslims made a case for Indian nationality based on their historic roots to Kashmir and the Indian government declared all Tibetan Muslims Indian citizens later on that year.
There is also a well established Chinese Muslim community gya kachee , which traces its ancestry back to the Hui ethnic group of China.
Tibetan representations of art are intrinsically bound with Tibetan Buddhism and commonly depict deities or variations of Buddha in various forms from bronze Buddhist statues and shrines, to highly colorful thangka paintings and mandalas.
Tibetan architecture contains Chinese and Indian influences, and reflects a deeply Buddhist approach. The Buddhist wheel , along with two dragons, can be seen on nearly every Gompa in Tibet.
The design of the Tibetan Chörtens can vary, from roundish walls in Kham to squarish, four-sided walls in Ladakh.
The most distinctive feature of Tibetan architecture is that many of the houses and monasteries are built on elevated, sunny sites facing the south, and are often made out of a mixture of rocks, wood, cement and earth.
Little fuel is available for heat or lighting, so flat roofs are built to conserve heat, and multiple windows are constructed to let in sunlight.
Walls are usually sloped inwards at 10 degrees as a precaution against the frequent earthquakes in this mountainous area. Standing at metres feet in height and metres 1, feet in width, the Potala Palace is the most important example of Tibetan architecture.
Formerly the residence of the Dalai Lama , it contains over one thousand rooms within thirteen stories, and houses portraits of the past Dalai Lamas and statues of the Buddha.
It is divided between the outer White Palace, which serves as the administrative quarters, and the inner Red Quarters, which houses the assembly hall of the Lamas, chapels, 10, shrines, and a vast library of Buddhist scriptures.
The music of Tibet reflects the cultural heritage of the trans-Himalayan region, centered in Tibet but also known wherever ethnic Tibetan groups are found in India, Bhutan , Nepal and further abroad.
First and foremost Tibetan music is religious music , reflecting the profound influence of Tibetan Buddhism on the culture. Tibetan music often involves chanting in Tibetan or Sanskrit , as an integral part of the religion.
These chants are complex, often recitations of sacred texts or in celebration of various festivals. Yang chanting, performed without metrical timing, is accompanied by resonant drums and low, sustained syllables.
Other styles include those unique to the various schools of Tibetan Buddhism, such as the classical music of the popular Gelugpa school, and the romantic music of the Nyingmapa , Sakyapa and Kagyupa schools.
Nangma dance music is especially popular in the karaoke bars of the urban center of Tibet, Lhasa. Another form of popular music is the classical gar style, which is performed at rituals and ceremonies.
Lu are a type of songs that feature glottal vibrations and high pitches. There are also epic bards who sing of Gesar , who is a hero to ethnic Tibetans.
Tibet has various festivals, many for worshipping the Buddha,  that take place throughout the year. Losar is the Tibetan New Year Festival.
Preparations for the festive event are manifested by special offerings to family shrine deities, painted doors with religious symbols, and other painstaking jobs done to prepare for the event.
Tibetans eat Guthuk barley noodle soup with filling on New Year's Eve with their families. The Monlam Prayer Festival follows it in the first month of the Tibetan calendar , falling between the fourth and the eleventh days of the first Tibetan month.
It involves dancing and participating in sports events, as well as sharing picnics. The most important crop in Tibet is barley , and dough made from barley flour—called tsampa —is the staple food of Tibet.
This is either rolled into noodles or made into steamed dumplings called momos. Meat dishes are likely to be yak , goat, or mutton , often dried, or cooked into a spicy stew with potatoes.
Mustard seed is cultivated in Tibet, and therefore features heavily in its cuisine.